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Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects

AIMS: Based on in vitro data, there is evidence to suggest that cytochrome P450 (CYP) 2C8 is involved in the metabolism of selexipag and its active metabolite, ACT‐333679. The present study evaluated the possible pharmacokinetic interactions of selexipag with gemfibrozil, a strong CYP2C8 inhibitor,...

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Bibliografiske detaljer
Udgivet i:Br J Clin Pharmacol
Main Authors: Bruderer, Shirin, Petersen‐Sylla, Marc, Boehler, Margaux, Remeňová, Tatiana, Halabi, Atef, Dingemanse, Jasper
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698574/
https://ncbi.nlm.nih.gov/pubmed/28715853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13379
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