Comparison of the pharmacokinetics, pharmacodynamics and tolerability of tezosentan between caucasian and Japanese subjects

AIM: To investigate the pharmacokinetics, pharmacodynamics and tolerability of the dual endothelin receptor antagonist tezosentan in caucasian and Japanese subjects. METHODS: Twelve subjects of each ethnic origin were treated in a double-blind, randomized design with sequential 3-h infusions of 2.5,...

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Hlavní autoři: Dingemanse, Jasper, Gunawardena, Kulasiri A, van Giersbergen, Paul L M
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2006
Témata:
Pharmacokinetics & Pharmacodynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885037/
https://ncbi.nlm.nih.gov/pubmed/16542201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02586.x
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