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Influence of mild liver impairment on the pharmacokinetics of tezosentan, a drug excreted unchanged into bile
AIMS: To investigate the effect of mild liver impairment on the pharmacokinetics of tezosentan. METHODS: Eleven patients with mild liver impairment and eight healthy subjects received an intravenous infusion of 50 mg h(−1) tezosentan for 1 h. Plasma and urine concentrations were determined during an...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Blackwell Science Inc
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1884457/ https://ncbi.nlm.nih.gov/pubmed/14998431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01987.x |
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