Influence of mild and moderate hepatic impairment on axitinib pharmacokinetics

Objective: To evaluate the effects of hepatic impairment on the pharmacokinetics and safety of a single, oral axitinib dose in subjects with mild or moderate hepatic impairment. Methods: In this phase I, open-label, parallel-group study, a total of 24 subjects with either normal hepatic function (n ...

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Detalhes bibliográficos
Main Authors: Tortorici, Michael A., Toh, Melvin, Rahavendran, S. V., LaBadie, Robert R., Alvey, Christine W., Marbury, Thomas, Fuentes, Ernesto, Green, Matthew, Ni, Grace, Hee, Brian, Pithavala, Yazdi K.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2010
Assuntos:
Phase I Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171651/
https://ncbi.nlm.nih.gov/pubmed/20596748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-010-9477-4
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