Influence of different degrees of liver impairment on the pharmacokinetics of clazosentan

AIM: To investigate the effect of mild, moderate and severe liver impairment on the pharmacokinetics (PK), tolerability and safety of clazosentan, an intravenous endothelin receptor antagonist. METHODS: Healthy subjects with normal liver function (n = 8), subjects with mild (Child Pugh A, n = 8), an...

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Detaylı Bibliyografya
Asıl Yazarlar: Bruderer, Shirin, Detishin, Victor, Tsvitbaum, Nahum, Dingemanse, Jasper
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2011
Konular:
Pharmacokinetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018026/
https://ncbi.nlm.nih.gov/pubmed/21143501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03804.x
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