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Influence of different degrees of liver impairment on the pharmacokinetics of clazosentan
AIM: To investigate the effect of mild, moderate and severe liver impairment on the pharmacokinetics (PK), tolerability and safety of clazosentan, an intravenous endothelin receptor antagonist. METHODS: Healthy subjects with normal liver function (n = 8), subjects with mild (Child Pugh A, n = 8), an...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Blackwell Science Inc
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018026/ https://ncbi.nlm.nih.gov/pubmed/21143501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03804.x |
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