Co-administration of ketoconazole with H(1)-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects

AIMS: Two studies were conducted to evaluate the effects of coadministration of ketoconazole with two nonsedating antihistamines, ebastine and loratadine, on the QTc interval and on the pharmacokinetics of the antihistamines. METHODS: In both studies healthy male subjects (55 in one study and 62 in...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chaikin, P, Gillen, M S, Malik, M, Pentikis, H, Rhodes, G R, Roberts, D J
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2005
Sujets:
Pharmacokinetics/Pharmacodynamics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884782/
https://ncbi.nlm.nih.gov/pubmed/15752381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02348.x
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