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Co-administration of ketoconazole with H(1)-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects

AIMS: Two studies were conducted to evaluate the effects of coadministration of ketoconazole with two nonsedating antihistamines, ebastine and loratadine, on the QTc interval and on the pharmacokinetics of the antihistamines. METHODS: In both studies healthy male subjects (55 in one study and 62 in...

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Main Authors: Chaikin, P, Gillen, M S, Malik, M, Pentikis, H, Rhodes, G R, Roberts, D J
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884782/
https://ncbi.nlm.nih.gov/pubmed/15752381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02348.x
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