Co-administration of ketoconazole with H(1)-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects

AIMS: Two studies were conducted to evaluate the effects of coadministration of ketoconazole with two nonsedating antihistamines, ebastine and loratadine, on the QTc interval and on the pharmacokinetics of the antihistamines. METHODS: In both studies healthy male subjects (55 in one study and 62 in...

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Detalhes bibliográficos
Main Authors: Chaikin, P, Gillen, M S, Malik, M, Pentikis, H, Rhodes, G R, Roberts, D J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Pharmacokinetics/Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884782/
https://ncbi.nlm.nih.gov/pubmed/15752381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02348.x
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