HLA-DM catalytically enhances peptide dissociation by sensing peptide–MHC class II interactions throughout the peptide-binding cleft

Human leukocyte antigen-DM (HLA-DM) is an integral component of the major histocompatibility complex class II (MHCII) antigen-processing and -presentation pathway. HLA-DM shapes the immune system by differentially catalyzing peptide exchange on MHCII molecules, thereby editing the peptide-MHCII (pMH...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Reyes-Vargas, Eduardo, Barker, Adam P., Zhou, Zemin, He, Xiao, Jensen, Peter E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062162/
https://ncbi.nlm.nih.gov/pubmed/31969393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010645
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