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A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules.
In B cells, the non-classical human leukocyte antigens HLA-DO (DO) and HLA-DM (DM) are residents of lysosome-like organelles where they form tight complexes. DM catalyzes the removal of invariant chain-derived CLIP peptides from classical major histocompatibility complex (MHC) class II molecules, ch...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
1998
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170637/ https://ncbi.nlm.nih.gov/pubmed/9606180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.11.2971 |
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