Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice

Mammalian aging is associated with reduced tissue regeneration and loss of physiological integrity. With age, stem cells diminish in their ability to regenerate adult tissues, likely contributing to age‐related morbidity. Thus, we replaced aged hematopoietic stem cells (HSCs) with young‐donor HSCs u...

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Pubblicato in:Aging Cell
Autori principali: Guderyon, Michael J., Chen, Cang, Bhattacharjee, Anindita, Ge, Guo, Fernandez, Roman A., Gelfond, Jonathan A. L., Gorena, Karla M., Cheng, Catherine J., Li, Yang, Nelson, James F., Strong, Randy J., Hornsby, Peter J., Clark, Robert A., Li, Senlin
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Original Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059148/
https://ncbi.nlm.nih.gov/pubmed/32012439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13110
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