Mitochondrial metabolites extend lifespan

Disruption of mitochondrial respiration in the nematode Caenorhabditis elegans can extend lifespan. We previously showed that long‐lived respiratory mutants generate elevated amounts of α‐ketoacids. These compounds are structurally related to α‐ketoglutarate, suggesting they may be biologically rele...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Mishur, Robert J., Khan, Maruf, Munkácsy, Erin, Sharma, Lokendra, Bokov, Alex, Beam, Haley, Radetskaya, Oxana, Borror, Megan, Lane, Rebecca, Bai, Yidong, Rea, Shane L.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783347/
https://ncbi.nlm.nih.gov/pubmed/26729005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12439
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