Mitochondrial metabolites extend lifespan

Disruption of mitochondrial respiration in the nematode Caenorhabditis elegans can extend lifespan. We previously showed that long‐lived respiratory mutants generate elevated amounts of α‐ketoacids. These compounds are structurally related to α‐ketoglutarate, suggesting they may be biologically rele...

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Bibliografski detalji
Izdano u:Aging Cell
Glavni autori: Mishur, Robert J., Khan, Maruf, Munkácsy, Erin, Sharma, Lokendra, Bokov, Alex, Beam, Haley, Radetskaya, Oxana, Borror, Megan, Lane, Rebecca, Bai, Yidong, Rea, Shane L.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783347/
https://ncbi.nlm.nih.gov/pubmed/26729005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12439
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