DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans

Mitochondrial dysfunction underlies numerous age-related pathologies. In an effort to uncover how the detrimental effects of mitochondrial dysfunction might be alleviated, we examined how the nematode C. elegans not only adapts to disruption of the mitochondrial electron transport chain, but in many...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Munkácsy, Erin, Khan, Maruf H., Lane, Rebecca K., Borror, Megan B., Park, Jae H., Bokov, Alex F., Fisher, Alfred L., Link, Christopher D., Rea, Shane L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946786/
https://ncbi.nlm.nih.gov/pubmed/27420916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006133
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