Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson’s Disease

Glial cell-line-derived neurotrophic factor (GDNF) is a potent neuroprotective agent in cellular and animal models of Parkinson’s disease (PD). However, CNS delivery of GDNF in clinical trials has proven challenging due to blood-brain barrier (BBB) impermeability, poor diffusion within brain tissue,...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Chen, Cang, Guderyon, Michael J., Li, Yang, Ge, Guo, Bhattacharjee, Anindita, Ballard, Cori, He, Zhixu, Masliah, Eliezer, Clark, Robert A., O’Connor, Jason C., Li, Senlin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931095/
https://ncbi.nlm.nih.gov/pubmed/31890743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.11.013
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