GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice

Glial cell line-derived neurotrophic factor (GDNF) is the most potent neuroprotective agent tested in cellular and animal models of Parkinson’s disease (PD). However, CNS delivery of GDNF is restricted by the blood-brain barrier (BBB). Using total body irradiation as transplant preconditioning, we p...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Cang, Li, Xiuhua, Ge, Guo, Liu, Jingwei, Biju, K. C., Laing, Suzette D., Qian, Yusheng, Ballard, Cori, He, Zhixu, Masliah, Eliezer, Clark, Robert A., O’Connor, Jason C., Li, Senlin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882968/
https://ncbi.nlm.nih.gov/pubmed/29615705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23795-4
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