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Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease.

Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by progressive loss of dopamine neurons, leading to loss of motor coordination. However, PD is associated with a high rate of non-motor neuropsychiatric comorbities that often develop before the onset of movement s...

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Autori principali: Xiuhua Li, Laney Redus, Cang Chen, Paul A Martinez, Randy Strong, Senlin Li, Jason C O'Connor
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2013-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3744561?pdf=render
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