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Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis

For the biomanufacturing of protein biologics, establishing stable cell lines with high transgene transcription is critical for high productivity. Modern genome engineering tools can direct transgene insertion to a specified genomic locus and can potentially become a valuable tool for cell line gene...

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Bibliografski detalji
Izdano u:Biotechnol J
Glavni autori: O’Brien, Sofie A., Lee, Kyoungho, Fu, Hsu-Yuan, Lee, Zion, Le, Tung S., Stach, Christopher S., McCann, Meghan G., Zhang, Alicia Q., Smanski, Michael J., Somia, Nikunj V., Hu, Wei-Shou
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058118/
https://ncbi.nlm.nih.gov/pubmed/30024101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201800226
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