Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis

For the biomanufacturing of protein biologics, establishing stable cell lines with high transgene transcription is critical for high productivity. Modern genome engineering tools can direct transgene insertion to a specified genomic locus and can potentially become a valuable tool for cell line gene...

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Detalles Bibliográficos
Publicado en:Biotechnol J
Autores principales: O’Brien, Sofie A., Lee, Kyoungho, Fu, Hsu-Yuan, Lee, Zion, Le, Tung S., Stach, Christopher S., McCann, Meghan G., Zhang, Alicia Q., Smanski, Michael J., Somia, Nikunj V., Hu, Wei-Shou
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058118/
https://ncbi.nlm.nih.gov/pubmed/30024101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201800226
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