Model-driven engineering of N-linked glycosylation in Chinese Hamster Ovary cells

Chinese Hamster Ovary (CHO) cells are used for industrial production of protein-based therapeutics (i.e. ‘biologics’). Here we describe a method for combining systems-level kinetic models with a synthetic biology platform for multi-gene overexpression to rationally perturb N-linked glycosylation. Sp...

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Pubblicato in:ACS Synth Biol
Autori principali: Stach, Christopher S., McCann, Meghan G., O’Brien, Conor M., Le, Tung S., Somia, Nikunj, Chen, Xinning, Lee, Kyoungho, Fu, Hsu-Yuan, Daoutidis, Prodromos, Zhao, Liang, Hu, Wei-Shou, Smanski, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034315/
https://ncbi.nlm.nih.gov/pubmed/31596566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.9b00215
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