Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13–induced Mucostasis

Primary human bronchial epithelial cell (HBEC) cultures are a useful model for studies of lung health and major airway diseases. However, mechanistic studies have been limited by our ability to selectively disrupt specific genes in these cells. Here we optimize methods for gene targeting in HBECs by...

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Detaylı Bibliyografya
Yayımlandı:Am J Respir Cell Mol Biol
Asıl Yazarlar: Koh, Kyung Duk, Siddiqui, Sana, Cheng, Dan, Bonser, Luke R., Sun, Dingyuan I., Zlock, Lorna T., Finkbeiner, Walter E., Woodruff, Prescott G., Erle, David J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Thoracic Society 2020
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055692/
https://ncbi.nlm.nih.gov/pubmed/31596609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0266OC
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