EB1-dependent long survival of glioblastoma-grafted mice with the oral tubulin-binder BAL101553 is associated with inhibition of tumor angiogenesis

Glioblastoma (GBM) are aggressive brain tumors with limited treatment options. Cancer stem-like cells (CSLCs) contribute to GBM invasiveness, representing promising targets. BAL101553, a prodrug of BAL27862, is a novel small molecule tubulin-binding agent, promoting tumor cell death through spindle...

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Vydáno v:Oncotarget
Hlavní autoři: Bergès, Raphaël, Tchoghandjian, Aurélie, Sergé, Arnauld, Honoré, Stéphane, Figarella-Branger, Dominique, Bachmann, Felix, Lane, Heidi A., Braguer, Diane
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2020
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055546/
https://ncbi.nlm.nih.gov/pubmed/32165998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27374
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