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Autophagy Plays a Critical Role in Klotho Gene Deficiency-induced Arterial Stiffening and Hypertension

OBJECTIVE: Klotho is an anti-aging gene that shortens lifespan when disrupted and extends lifespan when overexpressed. This study investigated whether autophagy plays a role in Klotho gene deficiency-induced arterial stiffening and hypertension. METHODS: Klotho mutant heterozygous (KL+/−) mice and a...

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Foilsithe in:J Mol Med (Berl)
Main Authors: CHEN, Kai, SUN, Zhongjie
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055468/
https://ncbi.nlm.nih.gov/pubmed/31630227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-019-01841-6
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