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Anti-aging Gene Klotho Deficiency Promoted High Fat Diet-induced Arterial Stiffening via Inactivation of AMP-activated Protein Kinase

Klotho was originally discovered as an aging-suppressor gene. The objective of this study is to investigate if klotho gene deficiency affects high fat diet-induced arterial stiffening. Heterozygous Klotho deficient (KL(+/−)) mice and WT littermates were fed on high fat diet (HFD) or normal diet (ND)...

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Bibliografski detalji
Izdano u:Hypertension
Glavni autori: Lin, Yi, Chen, Jianglei, Sun, Zhongjie
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752379/
https://ncbi.nlm.nih.gov/pubmed/26781278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06825
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