The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside

The cellular methyl donor S-adenosylmethionine (SAM) and other endo/exogenous agents methylate DNA bases non-enzymatically into products interfering with replication and transcription. An important product is 3-methyladenine (m(3)A), which in Escherichia coli is removed by m(3)A-DNA glycosylase I (T...

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Publicat a:Front Microbiol
Autors principals: Grøsvik, Kristin, Tesfahun, Almaz Nigatu, Muruzábal-Lecumberri, Izaskun, Haugland, Gyri Teien, Leiros, Ingar, Ruoff, Peter, Kvaløy, Jan Terje, Knævelsrud, Ingeborg, Ånensen, Hilde, Alexeeva, Marina, Sato, Kousuke, Matsuda, Akira, Alseth, Ingrun, Klungland, Arne, Bjelland, Svein
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051996/
https://ncbi.nlm.nih.gov/pubmed/32158436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.00263
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