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Peripheral Opioid Receptor Antagonists for Opioid-Induced Constipation: A Primer on Pharmacokinetic Variabilities with a Focus on Drug Interactions

Opioid analgesics remain a treatment option for refractory acute and chronic pain, despite their potential risk for abuse and adverse events (AEs). Opioids are associated with several common AEs, but the most bothersome is opioid-induced constipation (OIC). OIC is often overlooked but has the potent...

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Publicat a:J Pain Res
Autors principals: Gudin, Jeffrey, Fudin, Jeffrey
Format: Artigo
Idioma:Inglês
Publicat: Dove 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049282/
https://ncbi.nlm.nih.gov/pubmed/32158255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S220859
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