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Peripheral Opioid Receptor Antagonists for Opioid-Induced Constipation: A Primer on Pharmacokinetic Variabilities with a Focus on Drug Interactions

Opioid analgesics remain a treatment option for refractory acute and chronic pain, despite their potential risk for abuse and adverse events (AEs). Opioids are associated with several common AEs, but the most bothersome is opioid-induced constipation (OIC). OIC is often overlooked but has the potent...

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Détails bibliographiques
Publié dans:J Pain Res
Auteurs principaux: Gudin, Jeffrey, Fudin, Jeffrey
Format: Artigo
Langue:Inglês
Publié: Dove 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049282/
https://ncbi.nlm.nih.gov/pubmed/32158255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S220859
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