Pharmacologic Profile of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation

Opioid-induced constipation (OIC) is a common side effect of opioid pharmacotherapy for the management of pain because opioid agonists bind to µ-opioid receptors in the enteric nervous system (ENS). Naloxegol, a polyethylene glycol derivative of naloxol, which is a derivative of naloxone and a perip...

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Bibliografische gegevens
Gepubliceerd in:J Pharmacol Exp Ther
Hoofdauteurs: Floettmann, Eike, Bui, Khanh, Sostek, Mark, Payza, Kemal, Eldon, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2017
Onderwerpen:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399635/
https://ncbi.nlm.nih.gov/pubmed/28336575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.239061
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