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Population Exposure‐Response Modeling of Naloxegol in Patients With Noncancer‐Related Pain and Opioid‐Induced Constipation

Naloxegol is a polyethylene glycol derivative of naloxone approved in the US as a once‐daily oral treatment for opioid‐induced constipation (OIC) in adults with chronic noncancer pain. Population exposure–response models were constructed based on data from two phase III studies comprising 1,331 adul...

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Detalles Bibliográficos
Publicado en:CPT Pharmacometrics Syst Pharmacol
Main Authors: Al‐Huniti, N, Nielsen, JC, Hutmacher, MM, Lappalainen, J, Cantagallo, K, Sostek, M
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961079/
https://ncbi.nlm.nih.gov/pubmed/27435972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12099
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