Population pharmacokinetics of naloxegol in a population of 1247 healthy subjects and patients

AIMS: Naloxegol, a polyethylene glycol conjugated derivative of the opioid antagonist naloxone, is in clinical development for treatment of opioid‐induced constipation (OIC). The aim of the study was to develop a population pharmacokinetic model describing the concentration vs. time profile of orall...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Al‐Huniti, Nidal, Chapel, Sunny, Xu, Hongmei, Bui, Khanh H., Sostek, Mark
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
Subjects:
Pharmacokinetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693583/
https://ncbi.nlm.nih.gov/pubmed/26317320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12756
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