Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation

BACKGROUND: Naldemedine (S‐297995) is a peripherally acting μ‐opioid receptor antagonist developed as a once‐daily oral drug for opioid‐induced constipation (OIC) in adults with chronic noncancer or cancer pain. This study characterized the pharmacological effects of naldemedine in vitro and in vivo...

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Detalhes bibliográficos
Publicado no:Neurogastroenterol Motil
Main Authors: Kanemasa, Toshiyuki, Koike, Katsumi, Arai, Tohko, Ono, Hiroko, Horita, Narumi, Chiba, Hiroki, Nakamura, Atsushi, Morioka, Yasuhide, Kihara, Tsuyoshi, Hasegawa, Minoru
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850587/
https://ncbi.nlm.nih.gov/pubmed/30821019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nmo.13563
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