Naldemedine in Japanese patients with opioid-induced constipation and chronic noncancer pain: open-label Phase III studies

INTRODUCTION: Naldemedine is a peripherally-acting µ-opioid-receptor antagonist, approved in Japan for opioid-induced constipation (OIC). In two open-label, single-arm, Phase III studies, we evaluated the safety and efficacy of naldemedine in Japanese patients with OIC receiving regular-use opioids...

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Vydáno v:J Pain Res
Hlavní autoři: Saito, Yoji, Yokota, Takaaki, Arai, Masatsugu, Tada, Yukio, Sumitani, Masahiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307491/
https://ncbi.nlm.nih.gov/pubmed/30613161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S175900
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