A practical framework and online tool for mutational signature analyses show inter-tissue variation and driver dependencies

Mutational signatures are patterns of mutations that arise during tumorigenesis. We present an enhanced, practical framework for mutational signature analyses. Applying these methods on 3,107 whole genome sequenced (WGS) primary cancers of 21 organs reveals known signatures and nine previously undes...

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Publicado en:Nat Cancer
Main Authors: Degasperi, Andrea, Amarante, Tauanne Dias, Czarnecki, Jan, Shooter, Scott, Zou, Xueqing, Glodzik, Dominik, Morganella, Sandro, Nanda, Arjun S., Badja, Cherif, Koh, Gene, Momen, Sophie E., Georgakopoulos-Soares, Ilias, Dias, João M. L., Young, Jamie, Memari, Yasin, Davies, Helen, Nik-Zainal, Serena
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048622/
https://ncbi.nlm.nih.gov/pubmed/32118208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-0027-5
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