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Intracellular receptor modulation: Novel approach to target GPCRs
Recent crystal structures of multiple G protein-coupled receptors (GPCRs) have revealed a highly conserved intracellular pocket that can be used to modulate these receptors from the inside. This novel intracellular site partially overlaps with the G protein and β-arrestin binding site, providing a n...
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| Veröffentlicht in: | Trends Pharmacol Sci |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7048003/ https://ncbi.nlm.nih.gov/pubmed/29653834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2018.03.002 |
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