Skeletal Toxicity Resulting from Exposure of Growing Male Rats to Coplanar PCB 126 is Associated with Disruption of Calcium Homeostasis and the GH-IGF-1 Axis and Direct Effects on Bone Formation

Skeletal toxicity has been reported following exposure to polychlorinated biphenyl (PCB) mixtures. However, molecular mechanisms remain poorly understood. We exposed groups of male 4-5 week-old Sprague-Dawley rats to 3,3’, 4, 4’, 5-pentachlorobiphenyl (PCB 126), a dioxin-like coplanar PCB congener b...

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Udgivet i:Arch Toxicol
Main Authors: Ronis, Martin J., Watt, James, Pulliam, Casey F., Williams, Ashlee E., Alund, Alexander W., Haque, Ezazul, Gadupudi, Gopi S., Robertson, Larry W
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047627/
https://ncbi.nlm.nih.gov/pubmed/31820026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-019-02645-w
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