Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat Is Aryl Hydrocarbon Receptor Dependent

Epidemiological evidence links polychlorinated biphenyls (PCBs) to skeletal toxicity, however mechanisms whereby PCBs affect bone are poorly studied. In this study, coplanar PCB 126 (5 μmol/kg) or corn oil vehicle was administered to N = 5 and 6 male and female, wild type (WT) or AhR −/− rats via in...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Williams, Ashlee E, Watt, James, Robertson, Larry W, Gadupudi, Gopi, Osborn, Michele L, Soares, Michael J, Iqbal, Khursheed, Pedersen, Kim B, Shankar, Kartik, Littleton, Shana, Maimone, Cole, Eti, Nazmin A, Suva, Larry J, Ronis, Martin J J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Organ Specific Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197949/
https://ncbi.nlm.nih.gov/pubmed/32119087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa030
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