Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat Is Aryl Hydrocarbon Receptor Dependent

Epidemiological evidence links polychlorinated biphenyls (PCBs) to skeletal toxicity, however mechanisms whereby PCBs affect bone are poorly studied. In this study, coplanar PCB 126 (5 μmol/kg) or corn oil vehicle was administered to N = 5 and 6 male and female, wild type (WT) or AhR −/− rats via in...

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Bibliografische gegevens
Gepubliceerd in:Toxicol Sci
Hoofdauteurs: Williams, Ashlee E, Watt, James, Robertson, Larry W, Gadupudi, Gopi, Osborn, Michele L, Soares, Michael J, Iqbal, Khursheed, Pedersen, Kim B, Shankar, Kartik, Littleton, Shana, Maimone, Cole, Eti, Nazmin A, Suva, Larry J, Ronis, Martin J J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Organ Specific Toxicology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197949/
https://ncbi.nlm.nih.gov/pubmed/32119087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa030
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