Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat Is Aryl Hydrocarbon Receptor Dependent

Epidemiological evidence links polychlorinated biphenyls (PCBs) to skeletal toxicity, however mechanisms whereby PCBs affect bone are poorly studied. In this study, coplanar PCB 126 (5 μmol/kg) or corn oil vehicle was administered to N = 5 and 6 male and female, wild type (WT) or AhR −/− rats via in...

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Dades bibliogràfiques
Publicat a:Toxicol Sci
Autors principals: Williams, Ashlee E, Watt, James, Robertson, Larry W, Gadupudi, Gopi, Osborn, Michele L, Soares, Michael J, Iqbal, Khursheed, Pedersen, Kim B, Shankar, Kartik, Littleton, Shana, Maimone, Cole, Eti, Nazmin A, Suva, Larry J, Ronis, Martin J J
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Organ Specific Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197949/
https://ncbi.nlm.nih.gov/pubmed/32119087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa030
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