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The structure of a Mycobacterium tuberculosis heme-degrading protein, MhuD, variant in complex with its product

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, requires iron for survival. In Mtb, MhuD is the cytosolic protein that degrades imported heme. MhuD is distinct, both in sequence and structure, from canonical heme oxygenases (HOs) but homologous with IsdG-type proteins. Canonic...

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Podrobná bibliografie
Vydáno v:Biochemistry
Hlavní autoři: Chao, Alex, Burley, Kalistyn H., Sieminski, Paul J., de Miranda, Rodger, Chen, Xiaorui, Mobley, David L., Goulding, Celia W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045704/
https://ncbi.nlm.nih.gov/pubmed/31638374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00726
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