A New Way to Degrade Heme: THE MYCOBACTERIUM TUBERCULOSIS ENZYME MhuD CATALYZES HEME DEGRADATION WITHOUT GENERATING CO

MhuD is an oxygen-dependent heme-degrading enzyme from Mycobacterium tuberculosis with high sequence similarity (∼45%) to Staphylococcus aureus IsdG and IsdI. Spectroscopic and mutagenesis studies indicate that the catalytically active 1:1 heme-MhuD complex has an active site structure similar to th...

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Detalhes bibliográficos
Main Authors: Nambu, Shusuke, Matsui, Toshitaka, Goulding, Celia W., Takahashi, Satoshi, Ikeda-Saito, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617252/
https://ncbi.nlm.nih.gov/pubmed/23420845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448399
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