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The structure of a Mycobacterium tuberculosis heme-degrading protein, MhuD, variant in complex with its product

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, requires iron for survival. In Mtb, MhuD is the cytosolic protein that degrades imported heme. MhuD is distinct, both in sequence and structure, from canonical heme oxygenases (HOs) but homologous with IsdG-type proteins. Canonic...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Chao, Alex, Burley, Kalistyn H., Sieminski, Paul J., de Miranda, Rodger, Chen, Xiaorui, Mobley, David L., Goulding, Celia W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045704/
https://ncbi.nlm.nih.gov/pubmed/31638374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00726
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