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Probing the Conformational and Energy Landscapes of KRAS Membrane Orientation

Membrane reorientation of oncogenic RAS proteins is emerging as an important modulator of their functions. Previous studies have shown that the most common orientations include those with either the three C-terminal α-helices (OS1) or N-terminal β-strands (OS2) of the catalytic domain facing the mem...

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Veröffentlicht in:J Phys Chem B
Hauptverfasser: Prakash, Priyanka, Gorfe, Alemayehu A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045699/
https://ncbi.nlm.nih.gov/pubmed/31554397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.9b05796
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