The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure

KRAS interacts with the inner leaflet of the plasma membrane (PM) using a hybrid anchor that comprises a lysine-rich polybasic domain (PBD) and a C-terminal farnesyl chain. Electrostatic interactions have been envisaged as the primary determinant of interactions between KRAS and membranes. Here, we...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhou, Yong, Prakash, Priyanka S., Liang, Hong, Gorfe, Alemayehu A., Hancock, John F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017956/
https://ncbi.nlm.nih.gov/pubmed/33526670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014605118
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