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A novel prenyl-polybasic domain code determines lipid-binding specificity of the K-Ras membrane anchor

Ras proteins must localize to the plasma membrane (PM) for biological function. The membrane anchor of the K-Ras4B isoform comprises a farnesylated and methylated C-terminal cysteine together with an adjacent hexa-lysine polybasic domain (PBD). Traditionally, polybasic sequences have been thought to...

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Detalhes bibliográficos
Publicado no:Small GTPases
Main Authors: Zhou, Yong, Hancock, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549719/
https://ncbi.nlm.nih.gov/pubmed/29239694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2017.1379583
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