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RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains

RAS proteins are lipid-anchored small GTPases that switch between the GTP-bound active and GDP-bound inactive states. RAS isoforms, including HRAS, NRAS and splice variants KRAS4A and KRAS4B, are some of the most frequently mutated proteins in cancer. In particular, constitutively active mutants of...

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Bibliografiske detaljer
Udgivet i:Front Mol Biosci
Main Authors: Zhou, Yong, Gorfe, Alemayehu A., Hancock, John F.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245699/
https://ncbi.nlm.nih.gov/pubmed/34222339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.686338
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