TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis

Myeloid-derived suppressor cells (MDSCs) are “polarized” myeloid cells that effectively promote tumorigenesis by inhibiting antitumor immunity. How myeloid cells acquire the protumoral properties during tumorigenesis is poorly understood. We report here that the polarity protein TIPE2 (tumor necrosi...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Yan, Dehong, Wang, Jinghui, Sun, Honghong, Zamani, Ali, Zhang, Honglin, Chen, Weihong, Tang, Aifa, Ruan, Qingguo, Yang, Xiaolu, Chen, Youhai H., Wan, Xiaochun
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2019
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041705/
https://ncbi.nlm.nih.gov/pubmed/31662347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182005
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