Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

Myeloid-derived suppressor cells (MDSCs) play crucial roles in tumorigenesis and their inhibition is critical for successful cancer immunotherapy. MDSCs undergo metabolic reprogramming from glycolysis to fatty acid oxidation (FAO) and oxidative phosphorylation led by lipid accumulation in tumor. Inc...

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Gepubliceerd in:Front Immunol
Hoofdauteurs: Yan, Dehong, Adeshakin, Adeleye O., Xu, Meichen, Afolabi, Lukman O., Zhang, Guizhong, Chen, Youhai H., Wan, Xiaochun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2019
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593140/
https://ncbi.nlm.nih.gov/pubmed/31275326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01399
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