Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

Myeloid-derived suppressor cells (MDSCs) play crucial roles in tumorigenesis and their inhibition is critical for successful cancer immunotherapy. MDSCs undergo metabolic reprogramming from glycolysis to fatty acid oxidation (FAO) and oxidative phosphorylation led by lipid accumulation in tumor. Inc...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Yan, Dehong, Adeshakin, Adeleye O., Xu, Meichen, Afolabi, Lukman O., Zhang, Guizhong, Chen, Youhai H., Wan, Xiaochun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593140/
https://ncbi.nlm.nih.gov/pubmed/31275326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01399
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