TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis

Myeloid-derived suppressor cells (MDSCs) are “polarized” myeloid cells that effectively promote tumorigenesis by inhibiting antitumor immunity. How myeloid cells acquire the protumoral properties during tumorigenesis is poorly understood. We report here that the polarity protein TIPE2 (tumor necrosi...

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Bibliographische Detailangaben
Veröffentlicht in:J Exp Med
Hauptverfasser: Yan, Dehong, Wang, Jinghui, Sun, Honghong, Zamani, Ali, Zhang, Honglin, Chen, Weihong, Tang, Aifa, Ruan, Qingguo, Yang, Xiaolu, Chen, Youhai H., Wan, Xiaochun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041705/
https://ncbi.nlm.nih.gov/pubmed/31662347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182005
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