Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance

Foxp3(+) regulatory T (T reg) cells are pivotal regulators of immune tolerance, with T cell receptor (TCR)–driven activated T reg (aT reg) cells playing a central role; yet how TCR signaling propagates to control aT reg cell responses remains poorly understood. Here we show that TCR signaling induce...

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Publicat a:J Exp Med
Autors principals: Do, Mytrang H., Wang, Xinxin, Zhang, Xian, Chou, Chun, Nixon, Briana G., Capistrano, Kristelle J., Peng, Min, Efeyan, Alejo, Sabatini, David M., Li, Ming O.
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7037250/
https://ncbi.nlm.nih.gov/pubmed/31649036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190848
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