Metabolic modifier screen reveals secondary targets of protein kinase inhibitors within nucleotide metabolism

Biosynthesis of the pyrimidine nucleotide uridine monophosphate (UMP) is essential for cell proliferation and is achieved by the activity of convergent de novo and salvage metabolic pathways. Here we report the development and application of a cell-based metabolic modifier screening platform that le...

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Publicado no:Cell Chem Biol
Main Authors: Abt, Evan R., Rosser, Ethan W., Durst, Matthew A., Lok, Vincent, Poddar, Soumya, Le, Thuc M., Cho, Arthur, Kim, Woosuk, Wei, Liu, Song, Janet, Capri, Joseph R., Xu, Shili, Wu, Nanping, Slavik, Roger, Jung, Michael E., Damoiseaux, Robert, Czernin, Johannes, Donahue, Timothy R., Lavie, Arnon, Radu, Caius G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035983/
https://ncbi.nlm.nih.gov/pubmed/31734178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.10.012
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