[(18)F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity

Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an important therapeutic and positron emission tomography (PET) imaging target in cancer. PET probes for dCK have been developed and are effective in mice but have suboptimal specificity...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Kim, Woosuk, Le, Thuc M., Wei, Liu, Poddar, Soumya, Bazzy, Jimmy, Wang, Xuemeng, Uong, Nhu T., Abt, Evan R., Capri, Joseph R., Austin, Wayne R., Van Valkenburgh, Juno S., Steele, Dalton, Gipson, Raymond M., Slavik, Roger, Cabebe, Anthony E., Taechariyakul, Thotsophon, Yaghoubi, Shahriar S., Lee, Jason T., Sadeghi, Saman, Lavie, Arnon, Faull, Kym F., Witte, Owen N., Donahue, Timothy R., Phelps, Michael E., Herschman, Harvey R., Herrmann, Ken, Czernin, Johannes, Radu, Caius G.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839461/
https://ncbi.nlm.nih.gov/pubmed/27035974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524212113
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