ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways

Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibition of the replication stress sensing kinase ataxia telangiectasia and Rad3-related protein...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Le, Thuc M., Poddar, Soumya, Capri, Joseph R., Abt, Evan R., Kim, Woosuk, Wei, Liu, Uong, Nhu T., Cheng, Chloe M., Braas, Daniel, Nikanjam, Mina, Rix, Peter, Merkurjev, Daria, Zaretsky, Jesse, Kornblum, Harley I., Ribas, Antoni, Herschman, Harvey R., Whitelegge, Julian, Faull, Kym F., Donahue, Timothy R., Czernin, Johannes, Radu, Caius G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556071/
https://ncbi.nlm.nih.gov/pubmed/28808226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00221-3
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker